Verma M
Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, D.C. 20007, USA.
Cancer Biochem Biophys. 1994 Oct;14(3):151-62.
Mucin is a viscous secretion of glycoproteins secreted by epithelial cells of normal and cancerous tissues. Excessive and abnormal mucin synthesis has been observed in a number of cancers. The conformation and configuration of the surface carbohydrates play a key role in generating multiple forms of mucins in different cancers. The epitopes on the surface of mucin are recognized by antibodies present in different cancer cells. The primary structure of some of the cancer-associated mucins has been determined by molecular cloning of their complementary DNAs. The detection methods for cancer-associated mucins and their clinical applications are discussed.
粘蛋白是正常组织和癌组织的上皮细胞分泌的一种糖蛋白粘性分泌物。在许多癌症中都观察到了粘蛋白的过度和异常合成。表面碳水化合物的构象和构型在不同癌症中产生多种形式的粘蛋白方面起着关键作用。粘蛋白表面的表位被不同癌细胞中存在的抗体识别。一些与癌症相关的粘蛋白的一级结构已通过其互补DNA的分子克隆得以确定。本文讨论了与癌症相关的粘蛋白的检测方法及其临床应用。
