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具有血栓素A2合成酶抑制和支气管扩张双重活性的新型抗哮喘药。VI. 吲唑衍生物。

Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. VI. Indazole derivatives.

作者信息

Yamaguchi M, Maruyama N, Koga T, Kamei K, Akima M, Kuroki T, Hamana M, Ohi N

机构信息

Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd. Shizuoka, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1995 Feb;43(2):332-4. doi: 10.1248/cpb.43.332.

DOI:10.1248/cpb.43.332
PMID:7728936
Abstract

Synthesis and pharmacological evaluation of novel indazole derivatives are described. These compounds were found to exhibit both thromboxane A2 (TXA2) synthetase-inhibitory and bronchodilatory activities. This observation supports the idea that the partial structure of the 3-pyridyl and phenyl groups with a methylene insertion is an important component for well-balanced activities.

摘要

描述了新型吲唑衍生物的合成及药理评价。发现这些化合物具有血栓素A2（TXA2）合成酶抑制活性和支气管扩张活性。这一观察结果支持了这样一种观点，即带有亚甲基插入的3-吡啶基和苯基的部分结构是实现平衡活性的重要组成部分。

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