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具有血栓素A2合成酶抑制和支气管扩张双重活性的新型抗哮喘药。III. 4-[2-(5-乙基-2-噻吩基)]-2'-[2-(1-咪唑基)乙基]-1(2H)-酞嗪酮

Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. III. 4-[2-(5-ethyl-2-thienyl)]-2'-[2-(1-imidazolyl)ethyl]-1(2H)- phthalazinones.

作者信息

Yamaguchi M, Koga T, Kamei K, Akima M, Kuroki T, Hamana M, Ohi N

机构信息

Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd., Shizuoka, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1601-4. doi: 10.1248/cpb.42.1601.

DOI:10.1248/cpb.42.1601
PMID:7954911
Abstract

Synthesis and pharmacological evaluation of novel 4-[2-(5-ethyl-2-thienyl)]-2-[2-(1-imidazolyl)ethyl]-1(2H)-phthalazinone s are described. The phenyl moiety of the phthalazinone skeleton was found to play an important role in both thromboxane A2 synthetase-inhibitory and bronchodilatory activities.

摘要

描述了新型4-[2-(5-乙基-2-噻吩基)]-2-[2-(1-咪唑基)乙基]-1(2H)-酞嗪酮的合成及药理评价。发现酞嗪酮骨架的苯基部分在血栓素A2合成酶抑制活性和支气管扩张活性中均起重要作用。

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