Pennisi E M, Palladini G, Buttinelli C, Cusimano G, Galgani S, Lauro G, Fieschi C
Dipartimento di Scienze Neurologiche, La Sapienza University, Roma, Italy.
Clin Neuropathol. 1995 Jan-Feb;14(1):25-8.
Although several attempts at the immunohistochemical characterization of histiocytosis have recently been made there is only one paper which reports a case of cerebral Langerhans cell histiocytosis (LCH) diagnosed by biopsy. This paper presents a bioptically diagnosed case of juvenile histiocytosis. The panel of antibodies used was as follows: anti-S-100, 2 different antibodies to anti-interleukin 2, anti-lysozyme, anti-LEU M1, anti-MAC 387, anti-major histocompatibility complex II and anti-GFAP. Microglia markers--Griffonia simplicifolia and RCA 1 lectins were also utilized. The proliferating cells produced a positive response to S-100, lysozyme and a partially positive response to HLA DR, but responded negatively to MAC 387, LEU M1, lectins, IL2R and GFAP. Our results were compared and analyzed in the light of those obtained by other authors.
尽管最近有人尝试对组织细胞增多症进行免疫组织化学特征分析，但只有一篇论文报道了一例经活检诊断为脑朗格汉斯细胞组织细胞增多症（LCH）的病例。本文介绍了一例经活检诊断的青少年组织细胞增多症病例。所使用的抗体组合如下：抗S-100、两种不同的抗白细胞介素2抗体、抗溶菌酶、抗LEU M1、抗MAC 387、抗主要组织相容性复合体II和抗GFAP。还使用了小胶质细胞标志物——西非吊灯树凝集素和RCA 1凝集素。增殖细胞对S-100、溶菌酶产生阳性反应，对HLA DR产生部分阳性反应，但对MAC 387、LEU M1、凝集素、IL2R和GFAP产生阴性反应。我们的结果与其他作者获得的结果进行了比较和分析。
