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癌症广泛食管次全切除术后的5年生存率

[5-year survival after subtotal extensive esophagectomy for cancer].

作者信息

Collard J M, Kestens P J

机构信息

Service de Chirurgie de l'Appareil digestif, Cliniques universitaires Saint-Luc, Bruxelles, Belgique.

出版信息

Chirurgie. 1993;119(9):558-63; discussion 563-4.

PMID:7729205
Abstract

Over a seven year period, subtotal esophagectomy for cancer was performed on 125 patients (79.6% of the referred patients). Resection was potentially curative in 92, and it was palliative in 33. Potentially curative esophagectomies were carried out either by right thoracotomy, cervicotomy and laparotomy (n = 77), by combined transhiatal and transcervical approach without formal thoracotomy (n = 14), or by median sternotomy, cervicotomy and laparotomy (n = 1) depending on the tumor location in the esophagus and the general status of the patient. It included resection of the esophagus itself, and the lymph nodes and adjacent soft tissues located in the posterior mediastinum from the apex of the chest down to the diaphragm in patients operated on by right thoracotomy, in the posterior inferior mediastinum from the pulmonary veins down to the hiatus in those operated on by a transhiatal approach, and in the upper and lower mediastinum in those operated on transsternally. Twenty-eight patients operated on by potentially curative esophagectomy were given adjuvant radiotherapy or radiochemotherapy. Thirty-day and in-hospital postoperative mortalities were 0 and 2.4% (3/125), respectively. Five-year actuarial survival was 30% in the whole series, and 41% after potentially curative resection. In the latter instance, it was 48% for adenocarcinomas v.s. 38% for squamous cell carcinomas (p > 0.05), 38% after transthoracic resection v.s. 61% after transhiatal resection (p > 0.05), 44% after surgery alone v.s. 38% after surgery plus adjuvant therapy (p > 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

在七年的时间里,对125例患者(占转诊患者的79.6%)实施了食管癌次全切除术。92例切除可能治愈,33例为姑息性切除。根据食管肿瘤位置和患者一般状况,可能治愈性的食管切除术通过右胸切开术、颈部切开术和剖腹术(n = 77)、经裂孔和经颈部联合入路而不进行正式胸切开术(n = 14)或正中胸骨切开术、颈部切开术和剖腹术(n = 1)进行。它包括食管本身的切除,以及在接受右胸切开术的患者中,从胸顶部至膈肌切除后纵隔内的淋巴结和相邻软组织;在接受经裂孔入路手术的患者中,从肺静脉至裂孔切除后下纵隔内的组织;在接受胸骨切开术的患者中,切除上下纵隔内的组织。28例接受可能治愈性食管切除术的患者接受了辅助放疗或放化疗。术后30天和住院死亡率分别为0和2.4%(3/125)。整个系列的五年精算生存率为30%,可能治愈性切除后为41%。在后一种情况下,腺癌为48%,鳞状细胞癌为38%(p>0.05);经胸切除后为38%,经裂孔切除后为61%(p>0.05);单纯手术后为44%,手术加辅助治疗后为38%(p>0.05)。(摘要截断于250字)

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