Meyer C, De Manzini N, Rohr S, Thiry C L, Perraud V
Service de Chirurgie Générale et Digestive, Centre de Chirurgie Viscérale et de Transplantation, CHU de Strasbourg Hautepierre.
Chirurgie. 1994;120(2):107-12.
Thirty nine patients with a symptomatic gastrooesophageal reflux (RGO), resistant to or relapsing after medical treatment, were prospectively studied and operated on with a laparoscopic approach: 8 which a ligamentum teres cardiopexy, 31 with a 360 degrees fundoplicature. Both groups were comparable concerning clinical, endoscopic, mano- and pHmetric features (Anova test at 95% for all comparison in the study). There was no operative mortality. Conversion and morbidity rate were significantly higher (p = 0.04) in the "cardiopexy" group, even if data suggest a responsibility of the learning curve only. During follow-up patients were interviewed at 1, 3 and 12 months and proposed for mano- and pHmetry at 3 and 12 months. Late results at 12 months showed a relapse of RGO in 5 out of 8 patients of the "cardiopexy" group, with no relapse in "fundoplicature" group (p = 0.01). Mano- and pHmetric records showed at 3 months a persistent hypotony of the lower oesophageal sphincter and a persistent acid reflux in the "cardiopexy" group, with a significant (p = 0.01 and = 0.03) difference with "fundoplicature" group, in which lower oesophageal sphincter was hypercorrected and no reflux appeared at pHmetry. Despite some rare evidence in literature, cardiopexy do not give good late results, and laparoscopic 360 degrees fundoplicature seems to be the better procedure for surgical treatment of symptomatic RGO.
对39例有症状的胃食管反流(RGO)患者进行了前瞻性研究,这些患者药物治疗无效或复发,采用腹腔镜手术治疗:8例行贲门韧带固定术,31例行360度胃底折叠术。两组在临床、内镜、测压和pH值测量特征方面具有可比性(研究中所有比较均采用95%的方差分析检验)。无手术死亡。“贲门固定术”组的中转率和发病率显著更高(p = 0.04),即使数据表明这仅与学习曲线有关。在随访期间,于1、3和12个月对患者进行访谈,并在3和12个月时进行测压和pH值测量。12个月时的远期结果显示,“贲门固定术”组的8例患者中有5例RGO复发,“胃底折叠术”组无复发(p = 0.01)。测压和pH值测量记录显示,在3个月时,“贲门固定术”组食管下括约肌持续张力低下且持续存在酸反流,与“胃底折叠术”组有显著差异(p = 0.01和 = 0.03),在“胃底折叠术”组中食管下括约肌过度矫正,pH值测量时无反流出现。尽管文献中有一些罕见的证据,但贲门固定术的远期效果不佳,腹腔镜360度胃底折叠术似乎是治疗有症状RGO的更好手术方法。