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[保存骨髓自体移植对造血的刺激作用]

[Stimulating effect of autotransplantation of preserved bone marrow on hematopoiesis].

作者信息

Kovalenko P P, Baĭdaev A B

出版信息

Vestn Khir Im I I Grek. 1975 Apr;114(4):56-9.

PMID:772940
Abstract

In a given communication, the results of transplantation of autologous bone marrow, preserved at -50 degrees in the medium 199, added 10% low-molecular polyvinylpyrrolidone, are reported. Fourty two patients with pulmonary cancer of stage III and IV after pathohistological studies were subjected to chemoradiation therapy. The study of peripheral blood, the sternum and iliac bone needle biopsy specimens following this therapy has evidenced an inhibition of bone marrow hemopoiesis and of megakaryocytic growth, in particular. Autotransplantation of the preserved bone marrow against the background of inhibited hemopoiesis results in a nearly complete restoration of the bone marrow hemopoiesis.

摘要

在一次特定的交流中,报告了自体骨髓移植的结果,该自体骨髓保存在添加了10%低分子聚乙烯吡咯烷酮的199培养基中,温度为-50摄氏度。42例经病理组织学研究确诊为III期和IV期肺癌的患者接受了放化疗。对这些患者放化疗后的外周血、胸骨和髂骨穿刺活检标本进行研究后发现,骨髓造血功能,尤其是巨核细胞生长受到了抑制。在造血功能受抑制的情况下进行保存骨髓的自体移植,可使骨髓造血功能几乎完全恢复。

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