Kawatsu M, Yamashita T, Ishizuka M, Takeuchi T
Institute for Chemotherapy, M.C.R.F., Shizuoka, Japan.
J Antibiot (Tokyo). 1995 Mar;48(3):222-5. doi: 10.7164/antibiotics.48.222.
The antitumor efficacy of antitumor agents at sublethal doses was investigated in combination with conagenin (CNG) against murine leukemias. Mice were inoculated with 1 x 10(3) L1210 cells i.v. and given 300 mg/kg of cyclophosphamide (CY) i.p. on days 1 and 2 or on days 1, 5 and 9 after the tumor inoculation, and 5 mg/kg of CNG daily for 10 days. The administration of CNG was effective in increasing the number of cured mice and in prolonging the survival period of mice significantly, on both schedules of CY treatment. Moreover, the antitumor effect of CY against EL-4 was enhanced by CNG in increasing the number of cured mice, in CY treatment on days 1 and 2, and on days 1, 5 and 9. The effect of CNG was examined with mitomycin C (MMC) and adriamycin (ADM) at sublethal doses against leukemias. The antitumor effects of MMC at 10 mg/kg against L1210, and ADM at 15 mg/kg against P388 administered on days 1 and 5 were enhanced by CNG. Although mice treated with ADM at 15 mg/kg died earlier than non-treated controls on days 1 and 2 against L1210, P388 and EL-4, CNG with ADM was effective in prolonging the survival period.
研究了亚致死剂量的抗肿瘤药物与可那吉宁（CNG）联合使用对小鼠白血病的抗肿瘤疗效。给小鼠静脉注射1×10³个L1210细胞，并在接种肿瘤后的第1天和第2天或第1、5和9天腹腔注射300mg/kg环磷酰胺（CY），每天给予5mg/kg CNG，共10天。在CY治疗的两种方案中，CNG的给药均有效地增加了治愈小鼠的数量，并显著延长了小鼠的生存期。此外，在第1天和第2天以及第1、5和9天的CY治疗中，CNG增强了CY对EL-4的抗肿瘤作用，增加了治愈小鼠的数量。研究了亚致死剂量的丝裂霉素C（MMC）和阿霉素（ADM）与CNG联合使用对白血病的作用。在第1天和第5天给予10mg/kg MMC对L1210的抗肿瘤作用，以及15mg/kg ADM对P388的抗肿瘤作用，均因CNG而增强。尽管在第1天和第2天，15mg/kg ADM治疗的小鼠在针对L1210、P388和EL-4时比未治疗的对照组死亡更早，但CNG与ADM联合使用有效地延长了生存期。
