Kawatsu M, Yamashita T, Ishizuka M, Takeuchi T
Institute for Chemotherapy, M.C.R.F., Shizuoka, Japan.
Anticancer Res. 1996 Sep-Oct;16(5A):2937-41.
The effect of conagenin (CNG) on intestinal toxicity induction by 5-fluorouracil (5-Fu) was investigated. In mice given sublethal doses of 5-Fu (50mg/kg, i.v.) for 5 consecutive days, a decrease in body weight and diarrhea accompanied with hemorrhaging of the duodenum, atrophy of cecum and reduced small intestine length appeared. The administration of CNG in combination with 5-Fu inhibited thoe side effects induced by 5-Fu. Although all mice given 5-Fu alone were died within 13 days, 3 out of 10 mice treated with CNG survived for more than 21 days. The cytotoxicity of 5-Fu was not affected by CNG in vitro. The antitumor activity of 5-Fu was improved by CNG in increasing the number of surviving mice.
研究了松柏苷（CNG）对5-氟尿嘧啶（5-Fu）诱导肠道毒性的影响。给小鼠连续5天静脉注射亚致死剂量的5-Fu（50mg/kg）后，出现体重减轻、腹泻，并伴有十二指肠出血、盲肠萎缩和小肠长度缩短。CNG与5-Fu联合给药可抑制5-Fu诱导的这些副作用。虽然单独给予5-Fu的所有小鼠在13天内死亡，但10只接受CNG治疗的小鼠中有3只存活超过21天。在体外，5-Fu的细胞毒性不受CNG影响。CNG通过增加存活小鼠数量提高了5-Fu的抗肿瘤活性。
