Levêque J, Meunier B, Poulain P, Blanchot J, Dugast J, Le Prise E, Grall J Y
Service de Gynécologie-Obstétrique B, CHRU, Rennes.
J Gynecol Obstet Biol Reprod (Paris). 1995;24(1):9-12.
Development of diagnostic, therapeutic and preventive measures for breast cancer after cure of Hodgkin disease.
Presentation of 4 patients treated conjointly by the Radiotherapy and Gynaecology Surgery Departments of the Rennes University Hospital.
Illustrations of difficult management of breast cancer at different stages of diagnosis and therapy.
A past history of treated Hodgkin disease is a factor of risk for breast cancer and suggests the need for annual mammography screening 10 years after the end of treatment. Though more difficult, mastectomy is recommended over conservative radiosurgical treatment. The choice of drugs for adjuvant chemotherapy should rely on Hodgkin protocols and take into account heart function. Long-term carcinogenic effects of Hodgkin disease treatments requires modulation of the different treatment protocols as a function of stage, clinical and histological factors of prognosis and patient age.
制定霍奇金病治愈后乳腺癌的诊断、治疗和预防措施。
介绍4例由雷恩大学医院放疗科和妇科联合治疗的患者。
展示乳腺癌在诊断和治疗不同阶段的棘手处理情况。
既往有霍奇金病治疗史是乳腺癌的一个危险因素，提示在治疗结束10年后需每年进行乳腺钼靶筛查。尽管更具难度，但与保守性放射外科治疗相比，推荐行乳房切除术。辅助化疗药物的选择应依据霍奇金病治疗方案，并考虑心脏功能。霍奇金病治疗的长期致癌效应要求根据分期、临床和组织学预后因素以及患者年龄对不同治疗方案进行调整。
