Page W F, Ostfeld A M
Medical Follow-up Agency, Institute of Medicine, National Academy of Sciences, Washington, DC 20418, USA.
J Clin Epidemiol. 1994 Dec;47(12):1437-41. doi: 10.1016/0895-4356(94)90087-6.
The harsh treatment of former prisoners of war (POWs) of World War II and the Korean conflict resulted in severe malnutrition. Although rarely linked to specific long-term medical problems, a specific marker of malnutrition, self-reported lower limb edema (presumably due to a vitamin B deficiency) was associated with a three-fold increase in subsequent death attributed to ischemic heart disease (IHD) during the follow-up period from 1967 through 1975. Although there is at present no medical basis for linking edema, which is perhaps a marker for some unmeasured risk factor, to subsequent IHD, this finding may nonetheless have medical implications for the group of former POWs and other populations with severe dietary deficiency. It also suggests there may be a need to reexamine currently held theories on malnutrition and subsequent chronic disease.
二战及朝鲜冲突时期对战俘的残酷对待导致了严重营养不良。虽然营养不良很少与特定的长期医疗问题相关联，但一种营养不良的特定指标，即自我报告的下肢水肿（可能由于维生素B缺乏），与1967年至1975年随访期间因缺血性心脏病（IHD）导致的后续死亡风险增加三倍有关。尽管目前没有医学依据将水肿（可能是某些未测量风险因素的指标）与后续的缺血性心脏病联系起来，但这一发现可能对前战俘群体及其他存在严重饮食缺乏的人群具有医学意义。这也表明可能需要重新审视目前关于营养不良及后续慢性病的理论。
