Jespersen A
Acta Pathol Microbiol Scand C. 1976 Feb;84(1):1-4. doi: 10.1111/j.1699-0463.1976.tb03592.x.
Two lots of purified protein derivative of tuberculin with different potencies determined by skin tests on guinea pigs, were examined for their capacity to induce shock in hamsters sensitized with BCG. Groups of hamsters were injected with varying doses of a highly potent strain of BCG grown in Dubos fluid medium. 4-5 weeks later two groups of animals sensitized with corresponding doses were injected intraperitoneally with 1 mg of each lot of tuberculin. 12 of the 20 hamsters given the strong tuberculin died, while all those given the weak tuberculin survived. An attempt was made to evaluate the mutual potency of the two lots of tuberculin by injecting groups of sensitized animals with 1 mg strong or 4 mg weak tuberculin. The difference in the number of deaths from shock in the two groups was not significant.
通过对豚鼠进行皮肤试验测定了两种不同效价的结核菌素纯蛋白衍生物，检测它们在卡介苗致敏仓鼠中引发休克的能力。将仓鼠分组，注射不同剂量在杜博斯液体培养基中培养的高效力卡介苗菌株。4至5周后，两组分别用相应剂量致敏的动物腹腔注射每批1毫克的结核菌素。给予强效结核菌素的20只仓鼠中有12只死亡，而给予弱效结核菌素的仓鼠全部存活。通过给致敏动物组注射1毫克强效或4毫克弱效结核菌素，试图评估这两批结核菌素的相对效价。两组因休克死亡的数量差异不显著。
