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The biology of the P-glycoproteins.

作者信息

Leveille-Webster C R, Arias I M

机构信息

Tufts University School of Medicine, Department of Physiology, Boston, Massachusetts 02111, USA.

出版信息

J Membr Biol. 1995 Jan;143(2):89-102. doi: 10.1007/BF00234655.

DOI:10.1007/BF00234655
PMID:7731035
Abstract
摘要

相似文献

1
The biology of the P-glycoproteins.P-糖蛋白的生物学特性
J Membr Biol. 1995 Jan;143(2):89-102. doi: 10.1007/BF00234655.
2
Biology of the multidrug resistance-associated protein, MRP.多药耐药相关蛋白MRP的生物学特性
Eur J Cancer. 1996 Jun;32A(6):945-57. doi: 10.1016/0959-8049(96)00046-9.
3
A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein.药物脑-血清浓度比与P-糖蛋白影响之间的关系综述
Drug Metabol Drug Interact. 2007;22(2-3):113-29. doi: 10.1515/dmdi.2007.22.2-3.113.
4
P-glycoprotein: its role in drug resistance.P-糖蛋白:其在耐药性中的作用。
Am J Med. 1995 Dec 29;99(6A):31S-34S. doi: 10.1016/s0002-9343(99)80283-6.
5
What have we learnt thus far from mice with disrupted P-glycoprotein genes?到目前为止,我们从P-糖蛋白基因被破坏的小鼠身上了解到了什么?
Eur J Cancer. 1996 Jun;32A(6):985-90. doi: 10.1016/0959-8049(96)00063-9.
6
P-glycoprotein--a mediator of multidrug resistance in tumour cells.P-糖蛋白——肿瘤细胞多药耐药的一种介质。
Eur J Cancer. 1996 Jun;32A(6):927-44. doi: 10.1016/0959-8049(96)00057-3.
7
Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).揭示药物转运:P-糖蛋白多药转运体(ABCB1)的结构与功能
Biochem Cell Biol. 2006 Dec;84(6):979-92. doi: 10.1139/o06-199.
8
[Molecular mechanisms of chemotherapeutic resistance in genitourinary cancers].[泌尿生殖系统癌症化疗耐药的分子机制]
Nihon Hinyokika Gakkai Zasshi. 1998 Jan;89(1):1-13. doi: 10.5980/jpnjurol1989.89.1.
9
[Drug transporter studies in drug discovery and development].[药物发现与开发中的药物转运体研究]
Nihon Yakurigaku Zasshi. 2005 Apr;125(4):200-6. doi: 10.1254/fpj.125.200.
10
Unanswered questions about multidrug resistance.关于多药耐药性的未解决问题。
Cytotechnology. 1996;19(3):177-9. doi: 10.1007/BF00744209.

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Front Neurol. 2020 Feb 13;11:33. doi: 10.3389/fneur.2020.00033. eCollection 2020.
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genetic variants in leukemias: current insights into treatment outcomes.白血病中的基因变异:对治疗结果的当前见解
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Molecular analysis of the multidrug transporter, P-glycoprotein.

本文引用的文献

1
Evidence for the presence of a phosphatidylcholine translocator in isolated rat liver canalicular plasma membrane vesicles.在分离的大鼠肝胆小管质膜囊泡中存在磷脂酰胆碱转位体的证据。
J Biol Chem. 1993 Feb 25;268(6):3976-9.
2
Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases.酿酒酵母的基因SNQ2可赋予对4-硝基喹啉-N-氧化物和其他化学物质的抗性,它编码一种与ATP依赖性通透酶同源的169 kDa蛋白质。
Mol Gen Genet. 1993 Jan;236(2-3):214-8. doi: 10.1007/BF00277115.
3
MDR1 (multidrug resistance) gene expression in human primary liver cancer and cirrhosis.
多药转运蛋白 P-糖蛋白的分子分析。
Cytotechnology. 1998 Sep;27(1-3):31-60. doi: 10.1023/A:1008023629269.
4
Relationship between therapeutic efficacy of arterial infusion chemotherapy and expression of P-glycoprotein and p53 protein in advanced hepatocellular carcinoma.动脉灌注化疗对晚期肝细胞癌的疗效与P-糖蛋白和p53蛋白表达的关系
World J Gastroenterol. 2006 Feb 14;12(6):868-73. doi: 10.3748/wjg.v12.i6.868.
5
The mdr1a-/- mouse model of spontaneous colitis: a relevant and appropriate animal model to study inflammatory bowel disease.自发性结肠炎的mdr1a-/-小鼠模型:一种用于研究炎症性肠病的相关且合适的动物模型。
Immunol Res. 2005;31(2):151-9. doi: 10.1385/IR:31:2:151.
6
Detection of MDR1 single nucleotide polymorphisms C3435T and G2677T using real-time polymerase chain reaction: MDR1 single nucleotide polymorphism genotyping assay.使用实时聚合酶链反应检测多药耐药基因1(MDR1)单核苷酸多态性C3435T和G2677T:MDR1单核苷酸多态性基因分型检测
AAPS PharmSci. 2002;4(4):E29. doi: 10.1208/ps040429.
7
The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane.多药转运蛋白P-糖蛋白可主动介导细胞膜中的胆固醇重新分布。
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10347-52. doi: 10.1073/pnas.162366399. Epub 2002 Jul 26.
8
In vitro intestinal permeability of factor Xa inhibitors: influence of chemical structure on passive transport and susceptibility to efflux.凝血因子Xa抑制剂的体外肠道通透性:化学结构对被动转运及外排易感性的影响
Pharm Res. 2001 Dec;18(12):1735-41. doi: 10.1023/a:1013378731183.
9
Morphine antinociception is enhanced in mdr1a gene-deficient mice.多药耐药蛋白1a(mdr1a)基因缺陷型小鼠的吗啡镇痛作用增强。
Pharm Res. 2000 Jun;17(6):749-53. doi: 10.1023/a:1007546719287.
10
Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein.黄酮类化合物:一类在小鼠P-糖蛋白上邻近的ATP结合位点和类固醇结合位点具有双功能相互作用的调节剂。
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9831-6. doi: 10.1073/pnas.95.17.9831.
人原发性肝癌和肝硬化中多药耐药(MDR1)基因的表达
J Hepatol. 1993 Jun;18(2):168-72. doi: 10.1016/s0168-8278(05)80243-0.
4
Modulation of multidrug resistance: at the threshold.多药耐药性的调节:处于临界状态。
J Clin Oncol. 1993 Sep;11(9):1629-35. doi: 10.1200/JCO.1993.11.9.1629.
5
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective.体外TAP1依赖性肽转运是ATP依赖性且具有肽选择性的。
Cell. 1993 Aug 13;74(3):577-84. doi: 10.1016/0092-8674(93)80058-m.
6
Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine.恶性疟原虫对甲氟喹耐药性的选择与pfmdr1基因的扩增以及对卤泛群和奎宁的交叉耐药性有关。
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1143-7. doi: 10.1073/pnas.91.3.1143.
7
Intracellular pH and the control of multidrug resistance.细胞内pH值与多药耐药性的控制
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1128-32. doi: 10.1073/pnas.91.3.1128.
8
ABC transporters: bacterial exporters.ABC转运蛋白:细菌外排泵
Microbiol Rev. 1993 Dec;57(4):995-1017. doi: 10.1128/mr.57.4.995-1017.1993.
9
Phase I/pharmacokinetic study of high-dose progesterone and doxorubicin.高剂量孕酮与阿霉素的I期/药代动力学研究
J Clin Oncol. 1993 Dec;11(12):2417-26. doi: 10.1200/JCO.1993.11.12.2417.
10
Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii.恩氏利什曼原虫中一个染色体外扩增的多药耐药样基因的克隆与功能分析。
Mol Biochem Parasitol. 1993 Aug;60(2):195-208. doi: 10.1016/0166-6851(93)90131-g.