Nilsson K, Heimer G
Department of Obstetrics & Gynaecology, Orebro Medical Centre Hospital, Sweden.
Maturitas. 1995 Jan;21(1):33-8. doi: 10.1016/0378-5122(94)00865-5.
The vaginal absorption of oestradiol was studied during maintenance therapy with low-dose oestradiol. Six women with severe vaginal atrophy due to oestrogen deficiency were treated with a vaginal tablet containing 25 micrograms 17 beta-oestradiol. Initially, a daily dose was given for 2 weeks, followed by maintenance therapy with twice weekly treatment for another 10 weeks. The plasma concentrations of unconjugated oestrone and oestradiol were measured before oestrogen treatment was started at the beginning of the study. After 3 months of treatment frequent plasma sampling over a period of 24 h was performed. Gonadotrophins, vaginal and urethral cytology, clinical findings and subjective symptoms were assessed at the beginning and end of the study. Plasma concentrations of unconjugated oestradiol were at all times within the limits of postmenopausal values, but showed a slight but not statistically significant elevation after 3 months compared to pretreatment values. Plasma concentrations of unconjugated oestrone were in the low postmenopausal range throughout the study. LH levels were unaffected during the study, while FSH was somewhat lowered, but still well within the postmenopausal range. Vaginal and urethral cytology showed maturation with almost complete disappearance of parabasal cells. Clinical and subjective improvement was statistically significant during the treatment period.
在低剂量雌二醇维持治疗期间研究了雌二醇的阴道吸收情况。对6名因雌激素缺乏而患有严重阴道萎缩的女性，使用含25微克17β-雌二醇的阴道片进行治疗。最初，每日给药1次，持续2周，随后进行维持治疗，每周给药2次，持续10周。在研究开始雌激素治疗前，测定未结合雌酮和雌二醇的血浆浓度。治疗3个月后，在24小时内进行多次血浆采样。在研究开始和结束时评估促性腺激素、阴道和尿道细胞学、临床发现及主观症状。未结合雌二醇的血浆浓度始终处于绝经后水平范围内，但与治疗前值相比，3个月后略有升高，但无统计学意义。在整个研究过程中，未结合雌酮的血浆浓度处于绝经后低水平范围内。在研究期间，促黄体生成素水平未受影响，而促卵泡生成素略有降低，但仍处于绝经后范围内。阴道和尿道细胞学显示细胞成熟，基底旁细胞几乎完全消失。在治疗期间，临床和主观改善具有统计学意义。
