Varila E, Sievänen H, Vuori I, Oksanen H, Punnonen R
Department of Obstetrics and Gynaecology, University Hospital of Tampere, Finland.
Maturitas. 1995 Jan;21(1):45-9. doi: 10.1016/0378-5122(94)00859-6.
Measurement of skin thickness has been proposed to be capable of predicting low bone mineral density and the risk of osteoporosis in postmenopausal women. In order to investigate the association between the two factors, we measured skin thickness on the leg, lower abdomen and forearm by ultrasound scanning, and bone mineral density at the lumbar spine, femoral neck and distal radius by dual-energy X-ray absorptiometry in 60 peri- and postmenopausal women. Only a loose association was found between skin thickness and bone mineral density at any site, the highest correlation being between lumbar bone mineral density and abdominal skin thickness. The results of our study confirm that there is some association between the two factors, but the measurement of skin thickness, although easy and reliable, is not a clinically sufficient method to predict bone mineral density.
已有研究提出，测量皮肤厚度能够预测绝经后女性的低骨矿物质密度及骨质疏松风险。为了探究这两个因素之间的关联，我们对60名围绝经期和绝经后女性进行了如下测量：通过超声扫描测量腿部、下腹部和前臂的皮肤厚度，并用双能X线吸收法测量腰椎、股骨颈和桡骨远端的骨矿物质密度。结果发现，在任何部位，皮肤厚度与骨矿物质密度之间仅存在微弱关联，其中腰椎骨矿物质密度与腹部皮肤厚度的相关性最高。我们的研究结果证实，这两个因素之间确实存在一定关联，但尽管测量皮肤厚度简便可靠，却并非预测骨矿物质密度的充分临床方法。
