嘧啶并苯二氮䓬衍生物的合成与生物活性。新的环系：三唑并和四唑并嘧啶并苯二氮䓬。
Synthesis and biological activity of pyrimidobenzodiazepine derivatives. New ring systems: triazolo- and tetrazolo-pyrimido-benzodiazepines.
作者信息
Długosz A
机构信息
Department of Organic Chemistry, Medical University, Faculty of Pharmacy, Wrocław, Poland.
出版信息
Pharmazie. 1995 Mar;50(3):180-2.
PMID:7732047
Abstract
New triazolo- and tetrazolo-pyrimidobenzodiazepines were synthesized and screened as anti-HIV, anticancer and immunosuppressive agents. Some of the compounds showed immunosuppressive activity, similar to or stronger than that of cyclosporine A.
摘要
合成了新型三唑并和四唑并嘧啶苯二氮䓬类化合物，并作为抗艾滋病毒、抗癌和免疫抑制剂进行筛选。其中一些化合物表现出免疫抑制活性，与环孢素A相似或更强。
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