Abdel-Halim A M, el-Gendy Z, Abdel-Rahman R M
Department of Chemistry, Faculty of Education, Ain-Shams-University, Roxy, Cairo, Egypt.
Pharmazie. 1995 Nov;50(11):726-9.
The synthesis of 1,2,4-triazines bearing a 1,2,4-triazinone moiety and of 1,2,4-triazolo[4,3-b]-1,2,4-triazonones have been achieved by reaction of 1,6-dihydro-3-hydrazino-6-spiro- (9-fluorenyl)-1,2,4-triazin-5(4H)-one with various oxo- and halo-compounds. Structures of the products have been deduced by elemental analysis and spectral data. Significant anti-HIV and anticancer activities were observed in vitro for some members of the series.
通过1,6-二氢-3-肼基-6-螺-(9-芴基)-1,2,4-三嗪-5(4H)-酮与各种含氧化合物和卤代化合物的反应，实现了带有1,2,4-三嗪酮部分的1,2,4-三嗪以及1,2,4-三唑并[4,3-b]-1,2,4-三嗪酮的合成。通过元素分析和光谱数据推导了产物的结构。该系列的一些成员在体外表现出显著的抗HIV和抗癌活性。
