Nivas S C, York M D, Pomeroy B S
Am J Vet Res. 1976 Apr;37(4):433-7.
In vitro and in vivo transfers of antibiotic drug resistance were observed when isolates of multi-resistant Salmonella saint-paul and Escherichia coli donors were mated with multi-sensitive E coli and Salmonella typhimurium recipients, respectively. For in vivo studies, day-old turkey poults were used. Drug resistances were transferred either alone or in various combinations. In vitro, transfer was more frequent from E coli to S typhimurium; in vivo, transfer was more often observed from S saint-paul to E coli. Transfer occurred in vivo within 3 or 6 days after the recipient strain was given to poults previously infected with donor bacteria. In some instances, phage typing of S typhimurium indicated a change after transfer of drug resistance from E coli to S typhimurium. The criteria for in vivo transfer of drug resistance were discussed, and the implications of a change in phage type were noted.
当多重耐药的圣保罗沙门氏菌和大肠杆菌供体菌株分别与多重敏感的大肠杆菌和鼠伤寒沙门氏菌受体菌株进行接合时，观察到了抗生素耐药性的体外和体内转移。体内研究使用了一日龄的小火鸡。耐药性以单独或各种组合的形式进行转移。在体外，从大肠杆菌向鼠伤寒沙门氏菌的转移更为频繁；在体内，从圣保罗沙门氏菌向大肠杆菌的转移更为常见。在将受体菌株给予先前感染供体细菌的小火鸡后3或6天内，体内发生了转移。在某些情况下，对鼠伤寒沙门氏菌进行噬菌体分型表明，在耐药性从大肠杆菌转移到鼠伤寒沙门氏菌后发生了变化。讨论了体内耐药性转移的标准，并指出了噬菌体类型变化的影响。
