[The effect of an emulsion containing alpha-tocopherol and dimethylsulfoxide and of verapamil on reperfusion injury to the rat kidneys].

Four series of experiments were made on 82 rats which experienced 90-min renal ischemia. Animals from series 1 received no drugs. Animals of series 2 were injected i.v. emulsion (10 mg/kg alpha-tocopherol + 200 mg/kg dimethylsulphoxide) 10 min before ischemia termination. Animals of series 3 received i.v. verapamil (0.5 mg/kg) prior to reperfusion. Rats of series 4 were given alpha-tocopherol acetate emulsion simultaneously with verapamil. Introduction of alpha-tocopherol emulsion significantly inhibited lipid peroxidation (ascorbate-induced peroxidation activation) in intact kidneys blocking this activation in the reperfusion period. The ischemic kidney function proved much better on ischemia day 2 in the 2nd and 4th series. In series 3 the results were similar to control. On postischemia day 7 renal function did not differ much between the series. Mechanisms of the emulsion protective action and the causes of its absence in verapamil are covered in the discussion.