[Absence of a correlation between anti-oxidative and anti-ischemic effect of alpha-tocopherol in heat ischemia of the kidney].

Experiments were conducted on 110 inbred albino rats to compare the ability of alpha-tocopherol (alpha-TP), injected in a dose of 200 or 50 mg/kg 3, 6 or 24 hours before the experiment, to inhibit lipid peroxidation (LPO) in the cortex of a kidney after 90-minute ischemia with the influence of the drug on the function of the organ in the early postischemic period. Ischemia and alpha-TP had a mild effect on the basal malonic dialdehyde content in the kidney. Study of ascorbate-induced LPO showed it to be significantly activated in ischemia and after reperfusion, alpha-TP was also found to produce a marked inhibiting effect which grew with the gradual increase of the period between the injection of the agent and the development of ischemia. Injection of alpha-TP 24 hours before the experiment yielded data pointing indirectly to increased oxidation of renal lipids as compared to that in the controls. Twenty-four hours after ischemia LPO in the kidney was significantly inhibited both in the controls and in experiments with alpha-TP injection. On days 2 and 7 after ischemia the function of the kidneys did not improve in experiments with alpha-TP injection. The possible causes of a correlation between the antioxidative and antiischemic effects of alpha-TP are discussed.