Prasongsidkh B, Marokko I N, Krzhechkovskaia V V, Mamaeva E M
Vopr Pitan. 1994(6):3-5.
The study was made of aflatoxin B1 effect on guinea pig alimentary anaphylaxis to chicken ovalbumin (CO) and pasteurized cow milk (PCM), of CO-specific IgG antibody levels, some serum indices, sensitivity of the animals to LD50 histamine. In response to aflatoxin B1 alimentary anaphylaxis both to CO and PCM became more severe, lethality of the anaphylaxis to CO being in logarithmic relation to aflatoxin B1 dose (p < 0.05); specific IgG-antibodies to CO grew in number; serum total protein increased against unchanged levels of albumins; the activity of gamma-glutamyltransferase inhibited; histamine shock gained severity, its lethality being logarithmically related to the aflatoxin B1 dose. The discussion covers mechanisms underlying the animal allergic reactivity responses to aflatoxin B1.
该研究针对黄曲霉毒素B1对豚鼠对鸡卵清蛋白（CO）和巴氏杀菌牛奶（PCM）的食物过敏反应、CO特异性IgG抗体水平、一些血清指标以及动物对LD50组胺的敏感性的影响展开。针对黄曲霉毒素B1，对CO和PCM的食物过敏反应均变得更加严重，对CO过敏反应的致死率与黄曲霉毒素B1剂量呈对数关系（p < 0.05）；针对CO的特异性IgG抗体数量增加；血清总蛋白增加而白蛋白水平不变；γ-谷氨酰转移酶的活性受到抑制；组胺休克加剧，其致死率与黄曲霉毒素B1剂量呈对数关系。讨论内容涵盖了动物对黄曲霉毒素B1过敏反应性应答的潜在机制。
