Vilafranca M, Wohlsein P, Trautwein G, Leopold-Temmler B, Nolte I
Department of Pathology, School of Veterinary Medicine, Hannover, Germany.
Zentralbl Veterinarmed A. 1994 Oct;41(8):599-610. doi: 10.1111/j.1439-0442.1994.tb00127.x.
A histological and immunohistological study of the kidneys of 115 dogs, with and without clinical signs of spontaneous renal disease, was performed to prove the applicability of the WHO criteria for the classification of human glomerulopathy. Aside from the morphological investigation of paraffin and resin semithin sections, deposits of immunoglobulins, the complement component C3, and fibrinogen were observed immunoenzymatically in paraffin-embedded tissue specimens. From this, eight different types of glomerular lesions with various frequencies were identified: minor glomerular abnormalities (28 cases), focal and segmental hyalinosis and sclerosis (12 cases), focal glomerulonephritis (GN; 18 cases), diffuse membranous GN (nine cases), diffuse mesangial proliferative GN (2 cases), diffuse endocapillary proliferative GN (five cases), diffuse mesangiocapillary GN (25 cases), diffuse sclerosing GN (11 cases) und unclassified GN (two cases). In one case, renal dysplasia was diagnosed and two dogs did not present glomerular alterations. The results are discussed with regard to human glomerular diseases and pathogenic mechanisms.
对115只犬的肾脏进行了组织学和免疫组织学研究，这些犬有无自发性肾脏疾病的临床症状，目的是验证世界卫生组织（WHO）人类肾小球病分类标准的适用性。除了对石蜡和树脂半薄切片进行形态学研究外，还在石蜡包埋的组织标本中通过免疫酶法观察了免疫球蛋白、补体成分C3和纤维蛋白原的沉积。据此，确定了8种不同类型的肾小球病变，其出现频率各不相同：轻度肾小球异常（28例）、局灶节段性玻璃样变和硬化（12例）、局灶性肾小球肾炎（GN；18例）、弥漫性膜性GN（9例）、弥漫性系膜增生性GN（2例）、弥漫性毛细血管内增生性GN（5例）、弥漫性系膜毛细血管性GN（25例）、弥漫性硬化性GN（11例）及未分类的GN（2例）。有1例诊断为肾发育异常，2只犬未出现肾小球改变。结合人类肾小球疾病和致病机制对结果进行了讨论。
