Uehara F, Sameshima M, Unoki K, Okubo A, Yanagita T, Sugata M, Iwakiri N, Ohba N
Department of Ophthalmology, Kagoshima University Faculty of Medicine.
Nippon Ganka Gakkai Zasshi. 1995 Mar;99(3):286-8.
The binding of amaranthin, specific for Gal beta 1,3 GalNAc and sialic acid Gal beta 1,3 GalNAc sequences, to the human retina was investigated with avidin biotinylated peroxidase. Amaranthin bound to the cone and rod photoreceptors, inner plexiform layer, ganglion cells, and nerve fibers. Since peanut agglutinin, specific for Gal beta 1,3 GalNAc, selectively binds to cones, we conclude that O-glycoside-linked glycoconjugates are present on the surfaces of both cones and rods: Gal beta 1,3 GalNAc and sialic acid Gal beta 1,3 GalNAc are terminal sugars of the glycoconjugates around cones and rods, respectively.
