Hardy C L
University of Mississippi Medical Center, Jackson, USA.
Am J Med Sci. 1995 May;309(5):260-6. doi: 10.1097/00000441-199530950-00005.
In this article, the author discusses some of the most notable aspects of the work of Mehdi Tavassoli and others on the homing of intravenously transplanted hematopoietic stem cells to the marrow. It is well-recognized that homing of stem cells is a highly selective process, perhaps similar to the homing of lymphocytes to lymphoid tissues. The nature of the selectivity of stem cell homing is unclear, however, and may be mediated through a specific homing receptor or through a method of selective capture, retainment, or survival advantage afforded by the marrow. In this article, the focus is on current research in the identification of a specific homing receptor, the potential regulation of such a receptor by cytokines, the homing phenomenon as a multi-step process, and secondary adhesive interactions mediated by known adhesive molecules. These interactions may serve to strengthen the initial recognition and engraftment of stem cells within the hematopoietic compartment of the marrow.
在本文中，作者讨论了迈赫迪·塔瓦索利等人关于静脉内移植的造血干细胞归巢至骨髓的研究工作中一些最显著的方面。人们普遍认识到，干细胞归巢是一个高度选择性的过程，可能类似于淋巴细胞归巢至淋巴组织。然而，干细胞归巢选择性的本质尚不清楚，可能是通过特定的归巢受体介导，或者是通过骨髓提供的选择性捕获、保留或生存优势的方式介导。本文重点关注当前在识别特定归巢受体方面的研究、细胞因子对这种受体的潜在调节、归巢现象作为一个多步骤过程以及由已知黏附分子介导的次级黏附相互作用。这些相互作用可能有助于加强干细胞在骨髓造血区室内的初始识别和植入。
