Ishizaka K, Ishizaka T
Arch Pathol Lab Med. 1976 Jun;100(6):289-92.
Reaginic antibodies belong to IgE, which represents a distinct immunoglobulin class. Human IgE binds with basophil granulocytes and mast cells through the Fc portion of the molecules and mediates the release of chemical mediators that cause allergic symptoms. The initial step of the reaginic hypersensitivity reaction is probably the bridging of cell-bound IgE antibody by antigen. The reaction appears to initiate enzymatic sequences that lead to the release of chemical mediators. Measurement by radioimmunoassay of IgE and IgG antibodies in ragweed-sensitive hay fever patients has revealed immunologic effects of hyposensitization treatment. Experimental models for the immunotherapy in inbred mice strongly suggest that the major immunological effect would be depression of helper function of antigen-specific T cells. The results suggest logical approaches to improve the effect of the treatment.
反应素性抗体属于IgE，它代表一种独特的免疫球蛋白类别。人IgE通过分子的Fc部分与嗜碱性粒细胞和肥大细胞结合，并介导引起过敏症状的化学介质的释放。反应素性超敏反应的初始步骤可能是抗原使结合在细胞上的IgE抗体桥联。该反应似乎启动了导致化学介质释放的酶促序列。通过放射免疫测定法对豚草敏感的花粉症患者体内的IgE和IgG抗体进行测量，揭示了脱敏治疗的免疫学效应。近交系小鼠免疫治疗的实验模型有力地表明，主要的免疫学效应将是抗原特异性T细胞辅助功能的抑制。这些结果提示了改善治疗效果的合理方法。
