Martin S M, Malkinson T J, Veale W L, Pittman Q J
Neuroscience Research Group, Faculty of Medicine, University of Calgary, Alberta, Canada.
Am J Physiol. 1995 Apr;268(4 Pt 2):R919-23. doi: 10.1152/ajpregu.1995.268.4.R919.
Conscious virgin, pregnant, or lactating rats were given intravenous Escherichia coli endotoxin while their temperatures were monitored telemetrically. Virgin females responded to 10-50 micrograms/kg endotoxin with a slight hypothermia, followed by a fever of nearly 2 degrees C magnitude. In pregnant rats given 25 micrograms/kg of the endotoxin, fevers were reduced between 96 h before and 24 h after parturition compared with those seen in virgins or in lactating rats > 24 h postpartum. In the 24-h period before expected time of parturition, no rat developed a fever and the majority of animals became hypothermic; furthermore, in 80% of such animals given 25 micrograms/kg endotoxin, the hypothermia was accompanied by death within 3-15 h. Some mortality and hypothermia were also seen up to 48 h before birth and up to 24 h after birth. No mortality was observed in virgin, pregnant, or lactating rats outside of this time period. We conclude that, around the time of delivery, there is a suppression of fever in the rat and occasional toxic responses to endotoxin.
清醒的未孕、怀孕或泌乳大鼠静脉注射大肠杆菌内毒素，同时通过遥测技术监测其体温。未孕雌性大鼠对10 - 50微克/千克内毒素的反应先是轻度体温过低，随后体温升高近2摄氏度。给怀孕大鼠注射25微克/千克内毒素后，与未孕大鼠或产后24小时以上的泌乳大鼠相比，在分娩前96小时至分娩后24小时内发热反应减弱。在预期分娩时间前的24小时内，没有大鼠出现发热，大多数动物体温过低；此外，在80%注射25微克/千克内毒素的此类动物中，体温过低伴有在3 - 15小时内死亡。在出生前48小时和出生后24小时内也观察到一些死亡和体温过低情况。在此时间段之外，未孕、怀孕或泌乳大鼠均未观察到死亡情况。我们得出结论，在分娩前后，大鼠存在发热抑制以及对内毒素的偶尔毒性反应。
