Dodetskiĭ A S, Kazimirova N A, Timoshchenko O A, Zverev D V
Anesteziol Reanimatol. 1994 Nov-Dec(6):28-31.
Hemodynamic disorders occurring during acute renal failure (ARF) in children with the hemolytic uremic syndrome and the effects of peritoneal dialysis on hemodynamics were studied. A complex of electrophysiological methods was used: Integral whole body rheography, electrocardiography, and polycardiography, which permitted assessment of the severity and type of hemodynamic disorders in ARF. Three main types of hemodynamic changes were observed: hypodynamic, hyperdynamic, and normodynamic. The circulation regimen depended on the manifestation of extracardiac (hypovolemia, increase of the total peripheral resistance) and/or cardiac factors (reduction of the cardiac pump and contractile functions as a result of myo- or pericarditis, metabolic disorders in the myocardium). Specification of the hemodynamic diagnosis permitted a purposeful correction of the hemodynamic disorders (sympathomimetic amines, cardiac glycosides, vasodilators, infusion therapy). Peritoneal dialysis had an unfavorable effect on the hemodynamics of patients with impaired pump function of the myocardium and of those with hypovolemia, deteriorating at the same time the tolerance to volumic loading. Dopamine infusion reduced the hemodynamic disorders both "on an empty abdomen" and after filling of the abdominal cavity. Goal-oriented correction of the hemodynamics helped reduce the circulatory disorders during all stages of treatment of ARF.
研究了溶血尿毒综合征患儿急性肾衰竭(ARF)期间发生的血流动力学紊乱以及腹膜透析对血流动力学的影响。使用了一套电生理方法:整体全身血流图、心电图和多心电图,这些方法可用于评估ARF中血流动力学紊乱的严重程度和类型。观察到三种主要的血流动力学变化类型:低动力型、高动力型和正常动力型。循环状态取决于心外因素(血容量减少、总外周阻力增加)和/或心脏因素(由于心肌或心包炎导致心脏泵血和收缩功能降低、心肌代谢紊乱)的表现。血流动力学诊断的明确有助于有针对性地纠正血流动力学紊乱(拟交感神经胺、强心苷、血管扩张剂、输液治疗)。腹膜透析对心肌泵功能受损患者和血容量减少患者的血流动力学有不利影响,同时会降低对容量负荷的耐受性。多巴胺输注在“空腹”时和腹腔充盈后均可减轻血流动力学紊乱。有针对性地纠正血流动力学有助于在ARF治疗的各个阶段减少循环紊乱。