Saïssy J M, Guignard B, Pats B, Lenoir B, Rouvier B
Département d'Anesthésie-Réanimation, Hôpital d'Instruction des Armées Bégin.
Ann Fr Anesth Reanim. 1994;13(5):749-53. doi: 10.1016/s0750-7658(05)80736-1.
Two cases of severe complications due to injection of hydrogen peroxide under pressure into areas of muscular attrition in war wounds are reported. In both cases the administration of hydrogen peroxide was associated with tachypnoea, with major arterial desaturation and a precordial "mill-wheel" murmur was heard. In one case, these symptoms were followed by hemiplegia caused by paradoxical arterial gas embolism, and in the other case by a pulmonary oedema confirmed by computerized tomography. Both patients recovered under hyperbaric oxygen therapy. The release of gaseous oxygen under the effect of tissue catalase and the membrane peroxydasic activity of hydrogen peroxide initiate such complications. The injection of hydrogen peroxide under pressure into a closed or partially closed cavity should therefore be strictly prohibited.
报告了两例因在战伤肌肉萎缩部位加压注射过氧化氢而导致严重并发症的病例。在这两例中，注射过氧化氢均伴有呼吸急促、严重动脉血氧饱和度降低，并可闻及心前区“水车样”杂音。其中一例，这些症状随后出现由反常动脉气体栓塞引起的偏瘫，另一例经计算机断层扫描证实出现肺水肿。两名患者均在高压氧治疗下康复。组织过氧化氢酶作用下气态氧的释放以及过氧化氢的膜过氧化物酶活性引发了此类并发症。因此，应严格禁止在压力下将过氧化氢注射到封闭或部分封闭的腔隙中。
