渥曼青霉素的研究表明磷脂酰肌醇3激酶在胰岛素激活大鼠脂肪细胞中糖原合酶和丝裂原活化蛋白激酶过程中发挥作用：胰岛素与蛋白激酶C调节剂的比较
Studies with wortmannin suggest a role for phosphatidylinositol 3-kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat adipocytes: comparison of insulin and protein kinase C modulators.
作者信息
Standaert M L, Bandyopadhyay G, Farese R V
机构信息
J.A. Haley Veterans' Hospital, Department of Internal Medicine, University of South Florida College of Medicine, University of South Florida, Tampa 33612, USA.
出版信息
Biochem Biophys Res Commun. 1995 Apr 26;209(3):1082-8. doi: 10.1006/bbrc.1995.1608.
Wortmannin, a selective inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked insulin-induced activation of glycogen synthase (GS) and mitogen-activated protein kinase (MAPK) in rat adipocytes. These inhibitions were relatively specific, as wortmannin did not block GS activation by a protein kinase C (PKC) inhibitor, or MAPK activation by phorbol esters. Our findings suggest that PI3K is required for the activation of both GS and MAPK in rat adipocytes.
渥曼青霉素是一种磷脂酰肌醇3激酶（PI3K）的选择性抑制剂，它能阻断胰岛素诱导的大鼠脂肪细胞中糖原合酶（GS）的激活以及丝裂原活化蛋白激酶（MAPK）的激活。这些抑制作用具有相对特异性，因为渥曼青霉素不会阻断蛋白激酶C（PKC）抑制剂对GS的激活，也不会阻断佛波酯对MAPK的激活。我们的研究结果表明，PI3K是大鼠脂肪细胞中GS和MAPK激活所必需的。
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