PI-3激酶抑制剂渥曼青霉素可阻断生长激素在离体大鼠脂肪细胞中的胰岛素样作用。
PI-3-kinase inhibitor Wortmannin blocks the insulin-like effects of growth hormone in isolated rat adipocytes.
作者信息
Ridderstråle M, Tornqvist H
机构信息
Department of Paediatrics, University of Lund, Sweden.
出版信息
Biochem Biophys Res Commun. 1994 Aug 30;203(1):306-10. doi: 10.1006/bbrc.1994.2182.
The effect of wortmannin, a selective phosphatidylinositol 3-kinase inhibitor, on the insulin-like effects of growth hormone in isolated adipocytes from rat was investigated. Wortmannin inhibited both the lipogenic and the antilipolytic effects (IC50 approximately 20 nM) with no effect on [125I]-growth hormone binding to the adipocytes. These data suggest that phosphatidylinositol 3-kinase might play an important role in the insulin-like actions of growth hormone.
研究了选择性磷脂酰肌醇3激酶抑制剂渥曼青霉素对大鼠分离脂肪细胞中生长激素胰岛素样作用的影响。渥曼青霉素抑制了脂肪生成和抗脂解作用（IC50约为20 nM），对[125I] -生长激素与脂肪细胞的结合没有影响。这些数据表明磷脂酰肌醇3激酶可能在生长激素的胰岛素样作用中起重要作用。
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