Ibrahim M A, Chain B M, Katz D R
Dept of Immunology, University College London Medical School, UK.
Immunol Today. 1995 Apr;16(4):181-6. doi: 10.1016/0167-5699(95)80118-9.
A major unresolved paradox in immunology remains: how do we avoid harm, despite the abundant opportunities for induction of immune responses against self-proteins? Here, Mohammad Ibrahim, Benjamin Chain and David Katz extend Janeway's proposed explanation, arguing that adaptive immune responses are initiated not only by conserved microbial products, but also by microenvironmental tissue injury. They suggest that the key step is local dendritic cell activation, followed by upregulation of T-cell costimulatory molecules on these cells, and migration, leading to antigen presentation.
尽管有大量机会引发针对自身蛋白质的免疫反应，我们是如何避免伤害的？在此，穆罕默德·易卜拉欣、本杰明·钱恩和大卫·卡茨扩展了扬威提出的解释，认为适应性免疫反应不仅由保守的微生物产物引发，也由微环境组织损伤引发。他们指出关键步骤是局部树突状细胞激活，随后这些细胞上的T细胞共刺激分子上调，以及迁移，从而导致抗原呈递。
