四氢大麻酚诱导的Lewis大鼠和Sprague-Dawley大鼠的位置和味觉厌恶。
THC-induced place and taste aversions in Lewis and Sprague-Dawley rats.
作者信息
Parker L A, Gillies T
机构信息
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
出版信息
Behav Neurosci. 1995 Feb;109(1):71-8. doi: 10.1037//0735-7044.109.1.71.
The hedonic properties of delta-9-tetrahydrocannabinol (THC) were assessed in place and taste conditioning paradigms in both Lewis and Sprague-Dawley rat strains. THC produced place avoidance, taste avoidance, and aversive taste reactivity responses in both strains. The Lewis strain displayed more aversive taste reactions and a stronger taste avoidance when conditioned with lower doses of THC than did the Sprague-Dawley strain of rats. THC is an anomalous drug of abuse that appears to be aversive to rats when assessed by these measures.
在Lewis和Sprague-Dawley两种品系的大鼠中，通过位置条件化和味觉条件化范式评估了δ-9-四氢大麻酚（THC）的享乐属性。THC在两种品系中均产生位置回避、味觉回避和厌恶味觉反应。与Sprague-Dawley品系的大鼠相比，Lewis品系在用低剂量THC进行条件化时表现出更多的厌恶味觉反应和更强的味觉回避。当通过这些指标进行评估时，THC是一种异常的滥用药物，对大鼠似乎具有厌恶作用。
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