术前血清肿瘤标志物与结直肠癌Dukes分期及生存情况的相关性
The association of preoperative serum tumour markers with Dukes' stage and survival in colorectal cancer.
作者信息
Lindmark G, Bergström R, Påhlman L, Glimelius B
机构信息
Department of Surgery, Akademiska sjukhuset, Uppsala, Sweden.
出版信息
Br J Cancer. 1995 May;71(5):1090-4. doi: 10.1038/bjc.1995.211.
Abstract
The tumour markers carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), TPS, CA 19-9, CA 50 and CA 242 were analysed in serum from 203 potentially curable colorectal cancer patients. The levels of all markers increased with increasing tumour stage, and all markers correlated with survival. Multivariate analyses indicated that the Dukes stage had the best prognostic explanatory power, followed by TPA. In the subset of 166 potentially cured patients, the prognostic information by the markers was substantially reduced. We conclude that preoperative serum tumour marker measurements have the potential to aid therapy selection, but also that their clinical usefulness is not immediately apparent.
摘要
对203例可能治愈的结直肠癌患者的血清进行了癌胚抗原（CEA）、组织多肽抗原（TPA）、TPS、CA 19-9、CA 50和CA 242等肿瘤标志物分析。所有标志物的水平均随肿瘤分期增加而升高，且所有标志物均与生存率相关。多因素分析表明，Dukes分期具有最佳的预后解释力，其次是TPA。在166例可能治愈的患者亚组中，标志物的预后信息大幅减少。我们得出结论，术前血清肿瘤标志物检测有可能辅助治疗选择，但它们的临床实用性并非立竿见影。
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