睾丸生殖细胞肿瘤细胞系对新型抗癌药物替莫唑胺具有极高的敏感性。
Exceptional sensitivity of testicular germ cell tumour cell lines to the new anti-cancer agent, temozolomide.
作者信息
Pera M F, Köberle B, Masters J R
机构信息
Department of Zoology, Oxford University, UK.
出版信息
Br J Cancer. 1995 May;71(5):904-6. doi: 10.1038/bjc.1995.176.
Abstract
Metastatic testicular germ cell tumours are cured in approximately 85% of patients using cisplatin-based combination chemotherapy. Patients who fail to respond have a poor prognosis, and there is a need for more effective treatments for cisplatin-resistant disease. In this study, it is shown that two of four cell lines derived from human non-seminomatous testicular germ cell tumours are exceptionally sensitive to temozolomide, a new imidazotetrazine which can cross the blood-brain barrier in mice. In addition, three pairs of cisplatin-resistant sublines show little cross-resistance to temozolomide. These data suggest that temozolomide might have activity against non-seminomatous testicular germ cell tumours which have relapsed following cisplatin-containing chemotherapy, and could have a role in the treatment of patients with metastatic lesions in the brain.
摘要
使用以顺铂为基础的联合化疗，约85%的转移性睾丸生殖细胞肿瘤患者可被治愈。对治疗无反应的患者预后较差，因此需要针对顺铂耐药疾病的更有效治疗方法。本研究表明，源自人类非精原性睾丸生殖细胞肿瘤的四个细胞系中有两个对替莫唑胺异常敏感，替莫唑胺是一种新型咪唑并四嗪，在小鼠体内可穿过血脑屏障。此外，三对顺铂耐药亚系对替莫唑胺几乎没有交叉耐药性。这些数据表明，替莫唑胺可能对含顺铂化疗后复发的非精原性睾丸生殖细胞肿瘤有活性，并且可能在治疗脑部有转移性病变的患者中发挥作用。
相似文献
1
Exceptional sensitivity of testicular germ cell tumour cell lines to the new anti-cancer agent, temozolomide.睾丸生殖细胞肿瘤细胞系对新型抗癌药物替莫唑胺具有极高的敏感性。
Br J Cancer. 1995 May;71(5):904-6. doi: 10.1038/bjc.1995.176.
2
Phase II trial of temozolomide in patients with cisplatin-refractory germ cell tumors.替莫唑胺治疗顺铂难治性生殖细胞肿瘤患者的II期试验。
Invest New Drugs. 2004 Apr;22(2):177-9. doi: 10.1023/B:DRUG.0000011794.21608.59.
3
Genetic basis of drug sensitivity in human testis tumour cells.人类睾丸肿瘤细胞中药物敏感性的遗传基础。
Int J Cancer. 1996 Feb 8;65(4):426-31. doi: 10.1002/(SICI)1097-0215(19960208)65:4<426::AID-IJC5>3.0.CO;2-Z.
4
Role of metallothionein in cisplatin sensitivity of germ-cell tumours.金属硫蛋白在生殖细胞肿瘤顺铂敏感性中的作用
Int J Cancer. 2000 Mar 15;85(6):777-81. doi: 10.1002/(sici)1097-0215(20000315)85:6<777::aid-ijc6>3.0.co;2-d.
5
Comparative cytotoxicity of oxaliplatin and cisplatin in non-seminomatous germ cell cancer cell lines.奥沙利铂和顺铂在非精原细胞性生殖细胞癌细胞系中的细胞毒性比较。
Invest New Drugs. 1997;15(2):109-14. doi: 10.1023/a:1005800520747.
6
Prognostic factors in patients progressing after cisplatin-based chemotherapy for malignant non-seminomatous germ cell tumours.基于顺铂的化疗后进展的恶性非精原细胞瘤患者的预后因素。
Br J Cancer. 1999 Jul;80(9):1392-9. doi: 10.1038/sj.bjc.6690534.
7
Brief report: phase II multicenter study of temozolomide in patients with cisplatin-resistant germ cell tumors.简要报告：替莫唑胺治疗顺铂耐药生殖细胞肿瘤患者的 II 期多中心研究。
Oncology. 2011;80(3-4):219-22. doi: 10.1159/000329041. Epub 2011 Jul 4.
8
DNA repair capacity and cisplatin sensitivity of human testis tumour cells.人类睾丸肿瘤细胞的DNA修复能力和顺铂敏感性
Int J Cancer. 1997 Mar 4;70(5):551-5. doi: 10.1002/(sici)1097-0215(19970304)70:5<551::aid-ijc10>3.0.co;2-g.
9
Current trends in chemotherapy for metastatic nonseminomatous testicular germ cell tumors.转移性非精原细胞瘤性睾丸生殖细胞肿瘤化疗的当前趋势
Oncology. 1998 May-Jun;55(3):177-88. doi: 10.1159/000011854.
10
Sensitivity of testis tumour cells to chemotherapeutic drugs: role of detoxifying pathways.睾丸肿瘤细胞对化疗药物的敏感性：解毒途径的作用
Eur J Cancer. 1996 Jun;32A(7):1248-53. doi: 10.1016/0959-8049(96)00033-0.
引用本文的文献
1
Bis-Bibenzyls from the Liverwort and Their Biological Activity.来自地钱的双苄基化合物及其生物活性。
Plants (Basel). 2021 May 26;10(6):1063. doi: 10.3390/plants10061063.
2
MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients.O-甲基鸟嘌呤-DNA甲基转移酶（MGMT）和降钙素基因相关肽（CALCA）启动子甲基化与睾丸生殖细胞肿瘤患者的预后不良相关。
Oncotarget. 2016 Aug 10;8(31):50608-50617. doi: 10.18632/oncotarget.11167. eCollection 2017 Aug 1.
3
Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer.替莫唑胺-紫苏醇共轭物诱导的活性氧积累有助于其对非小细胞肺癌的细胞毒性。
Sci Rep. 2016 Mar 7;6:22762. doi: 10.1038/srep22762.
4
Impact of temozolomide on gonadal function in patients with primary malignant brain tumors.替莫唑胺对原发性恶性脑肿瘤患者性腺功能的影响。
J Oncol Pharm Pract. 2013 Dec;19(4):321-7. doi: 10.1177/1078155212469243. Epub 2013 Jan 4.
5
Phase II trial of temozolomide in patients with cisplatin-refractory germ cell tumors.替莫唑胺治疗顺铂难治性生殖细胞肿瘤患者的II期试验。
Invest New Drugs. 2004 Apr;22(2):177-9. doi: 10.1023/B:DRUG.0000011794.21608.59.
6
Primary central nervous system germ cell tumors.原发性中枢神经系统生殖细胞肿瘤
Curr Treat Options Oncol. 2003 Dec;4(6):491-8. doi: 10.1007/s11864-003-0049-0.
本文引用的文献
1
Hypersensitivity of human testis-tumour cell lines to chemotherapeutic drugs.人睾丸肿瘤细胞系对化疗药物的超敏反应。
Int J Cancer. 1993 Jan 21;53(2):340-6. doi: 10.1002/ijc.2910530228.
2
Brain metastasis as the site of relapse in germ cell tumor of testis.脑转移作为睾丸生殖细胞肿瘤复发的部位。
Cancer. 1993 Oct 1;72(7):2182-5. doi: 10.1002/1097-0142(19931001)72:7<2182::aid-cncr2820720719>3.0.co;2-p.
3
Increasing the dose intensity of chemotherapy in poor-prognosis metastatic non-seminoma.提高预后不良的转移性非精原细胞瘤化疗的剂量强度。
Eur Urol. 1993;23(1):219-22. doi: 10.1159/000474597.
4
Cell line derived from a metastasis of a human testicular germ cell tumor.源自人类睾丸生殖细胞肿瘤转移灶的细胞系。
Cancer Res. 1980 Jul;40(7):2500-6.
5
Established cell line of urinary bladder carcinoma (T24) containing tumour-specific antigen.建立的含有肿瘤特异性抗原的膀胱癌细胞系（T24）。
Int J Cancer. 1973 May;11(3):765-73. doi: 10.1002/ijc.2910110327.
6
7
Inherent sensitivity of cultured human embryonal carcinoma cells to adducts of cis-diamminedichloroplatinum(II) on DNA.培养的人胚胎癌细胞对顺二氨二氯铂（II）与DNA加合物的内在敏感性。
Cancer Res. 1987 Dec 15;47(24 Pt 1):6810-3.
8
Differential sensitivities of human testicular and bladder tumor cell lines to chemotherapeutic drugs.人睾丸和膀胱肿瘤细胞系对化疗药物的敏感性差异
J Natl Cancer Inst. 1987 Aug;79(2):213-6.
9
Cultured stem-cells from human testicular teratomas: the nature of human embryonal carcinoma, and its comparison with two types of yolk-sac carcinoma.源自人类睾丸畸胎瘤的培养干细胞：人类胚胎癌的本质及其与两种卵黄囊癌的比较。
Int J Cancer. 1987 Sep 15;40(3):334-43. doi: 10.1002/ijc.2910400309.
10
Development and characterization of cisplatin-resistant human testicular and bladder tumour cell lines.顺铂耐药的人睾丸和膀胱肿瘤细胞系的建立与鉴定
Eur J Cancer. 1990;26(6):742-7. doi: 10.1016/0277-5379(90)90133-e.
Zotero 插件