Warfvinge K
Institute of Environmental Health, Lund University, Sweden.
Int J Exp Pathol. 1995 Feb;76(1):29-35.
Female SJL/N mice were exposed to mercury vapour 5 days/week for 10 weeks, at a mercury concentration of approximately 0.5 mg/m3, 19 h/day; 1 mg/m3, 3 h/day; 0.3 mg/m3, 6 h/day or 1 mg/m3, 1.5 h/day. The total mercury concentrations in the brain were 6.4, 6.3, 1.6 and 0.64 micrograms/g tissue, respectively. The mercury distribution in the brains was examined. Mercury was found in almost the whole brain in the two groups with the highest exposure. In the third group, mercury was primarily found in the neocortical layer V, the white matter, thalamus, and the brain-stem. In the fourth group, the white matter and the brain-stem were the targets for mercury accumulation. Similarities and differences between rats and mice in the distribution pattern are discussed.
雌性SJL/N小鼠每周5天暴露于汞蒸气中，持续10周，汞浓度分别约为0.5毫克/立方米，每天19小时；1毫克/立方米，每天3小时；0.3毫克/立方米，每天6小时或1毫克/立方米，每天1.5小时。大脑中的总汞浓度分别为6.4、6.3、1.6和0.64微克/克组织。对大脑中的汞分布进行了检查。在暴露量最高的两组中，几乎整个大脑都发现了汞。在第三组中，汞主要存在于新皮质第V层、白质、丘脑和脑干。在第四组中，白质和脑干是汞积累的目标。讨论了大鼠和小鼠在分布模式上的异同。
