Holgers K M, Thomsen P, Tjellström A, Ericson L E
Department of Anatomy and Cell Biology, University of Göteborg, Sweden.
Biomaterials. 1995 Jan;16(2):83-90. doi: 10.1016/0142-9612(95)98267-i.
Percutaneous implants of titanium ad modum Brånemark have been in clinical use in the head and neck since 1977. The incidence of adverse reactions is low. In a previous study we have demonstrated the presence of inflammatory cells in the subcutaneous connective tissue surrounding the implants and this increased exposure to exogenous antigens was suggested to be compensated by a barrier of inflammatory cells in the soft tissue. To get further information on the nature of the tissue-implant contact, in the present study we have examined the structure of the tissue close to the percutaneous implant using transmission electron microscopy. We could not see evidence for an attachment of the epithelium to the implant, nor between the connective tissue and the implant. Retrieved implants were also analysed and we did not find any organized tissue remaining on the implants.
自1977年以来，类似Brånemark系统的钛质经皮植入物已在头颈部临床应用。不良反应发生率较低。在先前的一项研究中，我们已证实在植入物周围的皮下结缔组织中存在炎性细胞，并且认为软组织中炎性细胞形成的屏障可补偿这种对外源抗原暴露的增加。为了进一步了解组织与植入物接触的性质，在本研究中，我们使用透射电子显微镜检查了靠近经皮植入物的组织结构。我们未发现上皮附着于植入物的证据，也未发现结缔组织与植入物之间存在附着。我们还对取出的植入物进行了分析，未在植入物上发现任何有组织的残留组织。
