组成型和可变前体mRNA剪接中剪接位点选择的各个方面。
Aspects of splice site selection in constitutive and alternative pre-mRNA splicing.
作者信息
Inoue K, Ohno M, Shimura Y
机构信息
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
出版信息
Gene Expr. 1995;4(3):177-82.
Abstract
RNA splicing is an indispensable step for expression of many eukaryotic genes. Combinations of 5' and 3' splice sites should be correctly selected in both constitutive and alternative splicing. Recent studies have revealed mechanisms of alternative splicing in some systems, in which specific regulators play vital roles in splice site selection. On the other hand, essential splicing factors such as SR proteins modulate splice site usage of general machinery. Specific regulators and splicing factors such as SR proteins have some common structural features. With these related components, a similar machinery of splice site selection is involved in constitutive and alternative splicing.
摘要
RNA剪接是许多真核基因表达不可或缺的步骤。在组成型剪接和可变剪接中，都应正确选择5'和3'剪接位点的组合。最近的研究揭示了某些系统中可变剪接的机制，其中特定的调节因子在剪接位点选择中起着至关重要的作用。另一方面，诸如SR蛋白等必需的剪接因子调节一般剪接机制对剪接位点的使用。特定的调节因子和诸如SR蛋白等剪接因子具有一些共同的结构特征。有了这些相关成分，组成型剪接和可变剪接涉及类似的剪接位点选择机制。
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本文引用的文献
1
RNA recognition: a family matter?RNA识别：家族相关之事？
Cell. 1993 Jun 4;73(5):837-40. doi: 10.1016/0092-8674(93)90265-r.
2
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.异质性核糖核蛋白A1和前体mRNA剪接因子SF2/ASF对外显子跳跃和包含的调控
Mol Cell Biol. 1993 May;13(5):2993-3001. doi: 10.1128/mcb.13.5.2993-3001.1993.
3
The role of exon sequences in splice site selection.外显子序列在剪接位点选择中的作用。
Genes Dev. 1993 Mar;7(3):407-18. doi: 10.1101/gad.7.3.407.
4
The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element.心肌肌钙蛋白T可变外显子包含一个新的富含嘌呤的正性剪接元件。
Mol Cell Biol. 1993 Jun;13(6):3660-74. doi: 10.1128/mcb.13.6.3660-3674.1993.
5
Distinct functions of SR proteins in alternative pre-mRNA splicing.SR蛋白在可变前体mRNA剪接中的不同功能。
Science. 1993 Apr 9;260(5105):219-22. doi: 10.1126/science.8385799.
6
Specific commitment of different pre-mRNAs to splicing by single SR proteins.不同前体mRNA由单个SR蛋白进行剪接的特异性调控
Nature. 1993 Sep 2;365(6441):82-5. doi: 10.1038/365082a0.
7
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Mol Cell Biol. 1994 Feb;14(2):1347-54. doi: 10.1128/mcb.14.2.1347-1354.1994.
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