Berry H, Liyanage S P, Durance R A, Barnes C G, Berger L A, Evans S
Br Med J. 1976 May 1;1(6017):1052-4. doi: 10.1136/bmj.1.6017.1052.
Sixty-five patients, 33 receiving azathioprine and 32 receiving penicillamine, took part in a one-year, single-blind external-observer trial designed to compare the efficacy and toxicity of these two drugs in the treatment of rheumatoid arthritis. By six months there was a significantly greater rise in haemoglobin and fall in erythrocyte sedimentation rate among those receiving penicillamine, and by one year this difference remained only in the increase in haemoglobin levels. Fifteen patients, 10 on azathioprine and 5 on penicillamine, had to stop treatment because of side effects; 90 single side effects occurred, 48 in those on penicillamine and 42 in those on azathioprine. After one year both drugs were similar in efficacy and toxicity, but longer-term trials are needed. Both drugs were effective.
65名患者参与了一项为期一年的单盲外部观察者试验，其中33人服用硫唑嘌呤，32人服用青霉胺，旨在比较这两种药物治疗类风湿性关节炎的疗效和毒性。到6个月时，服用青霉胺的患者血红蛋白显著升高，红细胞沉降率下降，到1年时，这种差异仅体现在血红蛋白水平的升高上。15名患者因副作用不得不停止治疗，其中10人服用硫唑嘌呤，5人服用青霉胺；共出现90次单一副作用，服用青霉胺的患者有48次，服用硫唑嘌呤的患者有42次。1年后，两种药物在疗效和毒性方面相似，但需要进行更长时间的试验。两种药物均有效。
