氯芬酸与青霉胺。类风湿关节炎的对比试验。
Alclofenac and D-penicillamine. Comparative trial in rheumatoid arthritis.
作者信息
Berry H, Fernandes L, Ford-Hutchinson A W, Evans S J, Hamilton E B
出版信息
Ann Rheum Dis. 1978 Feb;37(1):93-7. doi: 10.1136/ard.37.1.93.
Abstract
Forty-six patients with rheumatoid arthritis, 22 receiving D-penicillamine and 2j alclofenac, took part in a 6-month single-bind external observer trial to compare the efficacy and toxicity of these drugs in the treatment of severe rheumatoid arthritis. Both drugs were active and similar in their efficacy at 6 months as judged by clinical and laboratory measurements. Penicillamine was active therapeutically by 3 months, one month before alclofenac. 9 patients, 8 on alclofenac and one on D-penicillamine, had to stop treatment because of lack of effect or toxic effects. Skin rashes within the first week of treatment were a major problem with alclofenac and led to 6 withdrawals.
摘要
46名类风湿性关节炎患者参与了一项为期6个月的单盲外部观察者试验，以比较青霉胺和阿氯芬酸这两种药物在治疗重度类风湿性关节炎时的疗效和毒性，其中22人服用青霉胺，24人服用阿氯芬酸。根据临床和实验室测量判断，两种药物均有活性，且在6个月时疗效相似。青霉胺在治疗3个月时开始显效，比阿氯芬酸早一个月。9名患者（8名服用阿氯芬酸，1名服用青霉胺）因无效或出现毒性作用而不得不停止治疗。治疗第一周出现的皮疹是阿氯芬酸的一个主要问题，导致6人停药。
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