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豚鼠瞬态诱发耳声发射的对侧抑制:庆大霉素的影响

Contralateral suppression of transient evoked otoacoustic emissions in guinea-pigs: effects of gentamicin.

作者信息

Aran J M, Erre J P, Avan P

机构信息

Laboratoire d'Audiologie Expérimentale, Hôpital Pellegrin, Bordeaux, France.

出版信息

Br J Audiol. 1994 Aug-Oct;28(4-5):267-71. doi: 10.3109/03005369409086576.

DOI:10.3109/03005369409086576
PMID:7735155
Abstract

A single injection of gentamicin in the awake guinea-pig induces a transient blockade of the suppression by contralateral white noise of tone-pip evoked compound action potential (Smith et al., 1994). We report here the reversible blockade, in exactly the same experimental conditions, of the suppression of click-evoked otoacoustic emissions. These observations confirm the transient action of gentamicin at the medial efferent/outer hair cell synapse, likely via the reversible blockade of calcium channels observed in vitro (Dulon et al., 1989).

摘要

在清醒的豚鼠体内单次注射庆大霉素会导致对侧白噪声对短纯音诱发的复合动作电位抑制作用的短暂阻断(史密斯等人,1994年)。我们在此报告,在完全相同的实验条件下,庆大霉素对短声诱发的耳声发射抑制作用的可逆阻断。这些观察结果证实了庆大霉素在内侧传出神经/外毛细胞突触处的短暂作用,可能是通过体外观察到的对钙通道的可逆阻断(迪隆等人,1989年)。

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引用本文的文献

1
The efferent-mediated suppression of otoacoustic emissions in awake guinea pigs and its reversible blockage by gentamicin.清醒豚鼠传出神经介导的耳声发射抑制及其被庆大霉素的可逆性阻断
Exp Brain Res. 1996 Apr;109(1):9-16. doi: 10.1007/BF00228621.