在使用阳离子交换树脂的氟代脱氧葡萄糖（FDG）合成中，乙酰保护基团的简单快速水解。

Simple rapid hydrolysis of acetyl protecting groups in the FDG synthesis using cation exchange resins.

作者信息

Mulholland G K

机构信息

Indiana University School of Medicine, Department of Radiology, Indianapolis 46202, USA.

出版信息

Nucl Med Biol. 1995 Jan;22(1):19-23. doi: 10.1016/0969-8051(94)e0068-t.

DOI:10.1016/0969-8051(94)e0068-t

PMID:7735165

Abstract

A new solid phase method for hydrolysis of acetyl groups from the intermediate 2-[18F]fluoro-2-deoxyglucose tetraacetate ([18F]FDG-Ac4) was developed. Fast cleavage occurs with Dowex 50 sulfonic acid resin (H+ form) at approximately 100 degrees C in the absence of bulk water. [18F]FDG-Ac4 reaction mixtures were efficiently converted to neutral aqueous solutions of pure FDG in 10-15 min. The method avoids problems associated with liquid acids and can be easily integrated into existing [18F]FDG procedures.

摘要

开发了一种从中间体2-[¹⁸F]氟-2-脱氧葡萄糖四乙酸酯（[¹⁸F]FDG-Ac4）中水解乙酰基的新固相方法。在没有大量水的情况下，使用Dowex 50磺酸树脂（H⁺形式）在约100℃时能快速裂解。[¹⁸F]FDG-Ac4反应混合物在10 - 15分钟内可有效转化为纯FDG的中性水溶液。该方法避免了与液态酸相关的问题，并且可以很容易地整合到现有的[¹⁸F]FDG程序中。