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Thin layer chromatographic detection of kryptofix 2.2.2 in the routine synthesis of [18F]2-fluoro-2-deoxy-D-glucose.

作者信息

Chaly T, Dahl J R

机构信息

Research Department, North Shore University Hospital, Manhasset, NY 11030.

出版信息

Int J Rad Appl Instrum B. 1989;16(4):385-7. doi: 10.1016/0883-2897(89)90105-0.

DOI:10.1016/0883-2897(89)90105-0
PMID:2777579
Abstract

A simple procedure for the detection of 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo (8.8.8) hexacosane (Kryptofix 2.2.2) in the final solution of [18F]FDG prepared by the aminopolyether supported nucleophilic substitution of 1,3,4,6-tetra-O-acetyl 2-O-trifluoromethanesulfonyl-beta-D-mannopyranose (Hamacher et al., 1986) has been developed. Presence of Kryptofix 2.2.2 in the routine production of [18F]FDG was detected using methanol/ammonium hydroxide (9:1) solvent system. A method to remove Kryptofix from [18F]FDG solution has been suggested.

摘要

相似文献

1
Thin layer chromatographic detection of kryptofix 2.2.2 in the routine synthesis of [18F]2-fluoro-2-deoxy-D-glucose.
Int J Rad Appl Instrum B. 1989;16(4):385-7. doi: 10.1016/0883-2897(89)90105-0.
2
Elimination of contaminant Kryptofix 2.2.2 in the routine production of 2-[18F]fluoro-2-deoxy-D-glucose.
Int J Rad Appl Instrum A. 1989;40(9):741-3. doi: 10.1016/0883-2889(89)90090-7.
3
A color spot test for the detection of Kryptofix 2.2.2 in [18F]FDG preparations.一种用于检测[18F]FDG制剂中Kryptofix 2.2.2的色斑试验。
Nucl Med Biol. 1997 Feb;24(2):193-5. doi: 10.1016/s0969-8051(96)00212-0.
4
Direct analysis of Kryptofix 2.2.2 in 18FDG by gas chromatography using a nitrogen-selective detector.
Nucl Med Biol. 1993 Apr;20(3):367-9. doi: 10.1016/0969-8051(93)90061-x.
5
Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution.使用氨基聚醚负载的亲核取代反应高效立体定向合成无载体添加的2-[¹⁸F] -氟-2-脱氧-D-葡萄糖。
J Nucl Med. 1986 Feb;27(2):235-8.
6
Back-to-back "one-pot" [18F]FDG syntheses in a single Siemens-CTI chemistry process control unit.
Nucl Med Biol. 1996 May;23(4):497-501. doi: 10.1016/0969-8051(96)00030-3.
7
Simple synthesis of F-18-labeled 2-fluoro-2-deoxy-D-glucose: concise communication.F-18标记的2-氟-2-脱氧-D-葡萄糖的简易合成：简要通讯
J Nucl Med. 1984 Mar;25(3):333-7.
8
Synthesis and purification of 2-deoxy-2-[18F]fluoro-D-glucose and 2-deoxy-2-[18F]fluoro-D-mannose: characterization of products by 1H- and 19F-NMR spectroscopy.2-脱氧-2-[¹⁸F]氟-D-葡萄糖和2-脱氧-2-[¹⁸F]氟-D-甘露糖的合成与纯化：通过¹H-和¹⁹F-NMR光谱对产物进行表征
Int J Rad Appl Instrum A. 1986;37(8):695-701. doi: 10.1016/0883-2889(86)90263-7.
9
Routine production of 2-deoxy-2-[18F]fluoro-D-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin.
Int J Rad Appl Instrum B. 1990;17(3):273-9. doi: 10.1016/0883-2897(90)90052-3.
10
Radiofluorination with xenon difluoride: a new high yield synthesis of [18F]2-fluro-2-deoxy-D-glucose.二氟化氙放射性氟化：[18F]2-氟-2-脱氧-D-葡萄糖的一种新的高产率合成方法。
Int J Appl Radiat Isot. 1983 Apr;34(4):743-5. doi: 10.1016/0020-708x(83)90254-5.

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