Atef N, Ktorza A, Pénicaud L
Laboratoire de Physiopathologie de la Nutrition, CNRS URA 307, Université Paris VII, France.
Int J Obes Relat Metab Disord. 1995 Feb;19(2):103-7.
The aim of this work was to study the role of the central nervous system in the glucose-induced increase in islet blood flow in obese Zucker rats.
A small amount of glucose (9 mg/kg) was injected towards the brain via the left carotid artery in lean obese rats either intact or vagotomized and after a pretreatment with clonidine.
Glucose injection induced a significant increase in plasma insulin level and islet blood flow without a significant change in plasma glucose concentration in both lean and obese rats. Prior vagotomy or clonidine injection resulted in a decrease in glucose-induced islet blood flow. Both the effect of glucose and its reversal were more pronounced in obese rats.
In obese rats, an alteration of the CNS could result in an increase in the parasympathetic tone and a decrease in the sympathetic one. These alterations would in turn contribute to the modifications in islet blood flow.
本研究旨在探讨中枢神经系统在肥胖 Zucker 大鼠葡萄糖诱导的胰岛血流增加中的作用。
对完整或经迷走神经切断术处理以及用可乐定预处理后的瘦型和肥胖 Zucker 大鼠，经左颈动脉向脑内注射少量葡萄糖（9 毫克/千克）。
在瘦型和肥胖大鼠中，注射葡萄糖均导致血浆胰岛素水平和胰岛血流显著增加，而血浆葡萄糖浓度无显著变化。预先进行迷走神经切断术或注射可乐定可导致葡萄糖诱导的胰岛血流减少。葡萄糖的作用及其逆转在肥胖大鼠中更为明显。
在肥胖大鼠中，中枢神经系统的改变可能导致副交感神经张力增加和交感神经张力降低。这些改变进而会导致胰岛血流的变化。
