Reddy N P, Patel K
Department of Biomedical Engineering, University of Akron, Ohio 44325-0302, USA.
Med Eng Phys. 1995 Mar;17(2):134-40. doi: 10.1016/1350-4533(95)91885-k.
Proper understanding of the mechanisms of fluid absorption and flow through the terminal lymphatics is essential for the control of several pathological conditions such as edema, bedsores and cancer. A mathematical model of the terminal lymphatics was developed using the principles of mechanics. Computer simulation results substantiate the hypothesis that fluid absorption and flow through the terminal lymphatics occur due to suction mechanisms of the adjacent contractile lymphatic segments and due to periodic fluctuations in the interstitial fluid pressure. In addition, the results suggested that increasing the length of a terminal lymphatic vessel beyond a certain limit does not cause further increase in fluid flow into the terminal lymphatic.
正确理解液体通过终末淋巴管的吸收和流动机制对于控制多种病理状况（如水肿、褥疮和癌症）至关重要。利用力学原理建立了终末淋巴管的数学模型。计算机模拟结果证实了以下假设：液体通过终末淋巴管的吸收和流动是由于相邻收缩性淋巴管段的抽吸机制以及间质液压力的周期性波动所致。此外，结果表明，将终末淋巴管的长度增加到超过一定限度不会导致流入终末淋巴管的液体流量进一步增加。
