Nagaoka R, Mizuno M, Yamashita S, Akaike N
Department of Physical Education, College of Liberal Arts, Kagoshima University, Japan.
Comp Biochem Physiol A Physiol. 1995 Apr;110(4):341-6. doi: 10.1016/0300-9629(94)00175-s.
The CNS-mediated inhibition of active Na(+)-K+ transport in both "type S" muscle, soleus (SOL), and "type FF" muscle, extensor digitorum longus (EDL) was investigated in rats suspended horizontally. Plasma Na+ and K+ contents did not change during the suspension period. The relative wet weight of SOL decreased more than that of EDL by suspension. There was significant intracellular Na+ accumulation and K+ loss in both SOL and diaphragm of suspended rats. However, cerebrum, cerebellum, medulla oblongate, ventricle, liver, pancreas, kidney, intestine, aorta and EDL were spared from the intracellular Na+ accumulation and K+ loss. Sciatic nerve sectioning or cervical spinal cord transection recovered the Na+ and K+ contents in the SOL of suspended rats. The results indicate the existence of neural inhibition of the active Na(+)-K+ transport in skeletal muscle of the suspended rats.
在水平悬吊的大鼠中，研究了中枢神经系统（CNS）介导的对“慢肌型”肌肉比目鱼肌（SOL）和“快肌型”肌肉趾长伸肌（EDL）中活性钠钾转运的抑制作用。在悬吊期间，血浆钠和钾含量没有变化。悬吊后，SOL的相对湿重比EDL下降得更多。悬吊大鼠的SOL和膈肌中均有明显的细胞内钠蓄积和钾流失。然而，大脑、小脑、延髓、脑室、肝脏、胰腺、肾脏、肠道、主动脉和EDL未出现细胞内钠蓄积和钾流失。切断坐骨神经或横断颈脊髓可使悬吊大鼠SOL中的钠和钾含量恢复正常。结果表明，悬吊大鼠骨骼肌中存在对活性钠钾转运的神经抑制作用。
