Miyamoto H, Kubota Y, Shuin T, Torigoe S, Dobashi Y, Hosaka M
Department of Urology, School of Medicine, Yokohama City University, Japan.
Cancer. 1995 May 15;75(10):2565-70. doi: 10.1002/1097-0142(19950515)75:10<2565::aid-cncr2820751025>3.0.co;2-m.
Elevated expression of transforming growth factor-beta 1 (TGF-beta 1) has been reported in several types of human cancer. However, the significance of TGF-beta 1 expression in clinical bladder cancer is not well known.
The levels of TGF-beta 1 expression were quantitated using a polymerase chain reaction-based method in tissue specimens obtained from 51 patients with bladder cancer.
Transforming growth factor-beta 1 expression in bladder cancer was higher than that found in normal bladder epithelium (P < 0.01). Significantly higher levels of TGF-beta 1 transcripts were observed in low and intermediate grade (Grade 1 and 2) tumors than in high grade (Grade 3) tumors (P < 0.02). Superficial (pTa and pT1) tumors had higher levels of TGF-beta 1 than invasive (pT2 or higher) tumors (P < 0.05).
These results suggest that enhanced expression of TGF-beta 1 is specific to low grade and stage bladder cancer. Transforming growth factor-beta 1 may play an important role in the early stages of human bladder cancer development, and TGF-beta 1 expression could provide a new relevant tumor marker for determining tumor progression in patients with bladder cancer.
据报道，转化生长因子-β1（TGF-β1）在多种人类癌症中表达升高。然而，TGF-β1表达在临床膀胱癌中的意义尚不清楚。
采用基于聚合酶链反应的方法对51例膀胱癌患者的组织标本中TGF-β1的表达水平进行定量分析。
膀胱癌中转化生长因子-β1的表达高于正常膀胱上皮（P < 0.01）。低级别和中级别的（1级和2级）肿瘤中TGF-β1转录本水平显著高于高级别（3级）肿瘤（P < 0.02）。浅表性（pTa和pT1）肿瘤的TGF-β1水平高于浸润性（pT2或更高）肿瘤（P < 0.05）。
这些结果表明，TGF-β1表达增强是低级别和低分期膀胱癌所特有的。转化生长因子-β1可能在人类膀胱癌发生的早期阶段起重要作用，TGF-β1表达可为确定膀胱癌患者的肿瘤进展提供一种新的相关肿瘤标志物。
