Vianna N J, Polan A K
Lancet. 1978 May 20;1(8073):1061-3. doi: 10.1016/s0140-6736(78)90911-x.
A study of the occupational histories of 52 females with malignant mesothelioma and certain of their relatives, carried out to measure the risk of this disorder attributable to indirect asbestos exposure, showed that a significantly greater number of husbands and fathers of cases than of controls worked in asbestos-related industries, and the relative risk for this factor was 10. The frequency of parental cancer, especially gastrointestinal malignancy, was also significantly greater for cases than for their controls. This raises the possibility of a genetic predisposition to malignant mesothelioma.
一项针对52名恶性间皮瘤女性患者及其部分亲属职业史的研究，旨在衡量因间接接触石棉而患此病的风险。研究表明，与对照组相比，病例组的丈夫和父亲在石棉相关行业工作的人数显著更多，该因素的相对风险为10。病例组的父母患癌频率，尤其是胃肠道恶性肿瘤的频率，也显著高于对照组。这增加了恶性间皮瘤存在遗传易感性的可能性。
