Tsakonas D P, Tsakona C P, Worman C P, Goldstone A H, Nicolaides K H
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital School of Medicine, London, UK.
Clin Lab Haematol. 1994 Dec;16(4):337-42. doi: 10.1111/j.1365-2257.1994.tb00431.x.
Myeloperoxidase (MPO) activity and nuclear segmentation of neutrophils were measured in peripheral blood samples from 90 normal pregnant women, arranged in nine groups of ten each, every four weeks at 8-40 weeks gestation and from 25 non-pregnant healthy female controls. A blood autoanalyser (Technicon H*1) was used to determine the mean peroxidase index (MPXI) and the lobularity index (LI) of circulating neutrophils. Mean MPXI levels in pregnancy decreased with gestation to a minimum at 20 weeks' gestation and increased thereafter to reach non-pregnant levels at 36 weeks. Mean LI values did not change significantly with gestation, but were significantly lower throughout pregnancy compared to controls. There was no significant association between MPXI and LI. It could be postulated that the fall in MPXI during mid-gestation is due to degranulation of neutrophils and the subsequent rise at the end of pregnancy could be a consequence of enhanced MPO activity under the influence of oestrogens. Low LI suggests the production of immature neutrophils during pregnancy.
在90名正常孕妇的外周血样本中测量了髓过氧化物酶（MPO）活性和中性粒细胞的核分叶情况。这些孕妇被分为9组，每组10人，在妊娠8至40周期间每四周进行一次检测，并与25名非妊娠健康女性对照者进行比较。使用血液自动分析仪（Technicon H*1）测定循环中性粒细胞的平均过氧化物酶指数（MPXI）和分叶指数（LI）。妊娠期间MPXI的平均水平随孕周增加而下降，在妊娠20周时降至最低，此后升高，在36周时达到非妊娠水平。LI的平均值在妊娠期间没有显著变化，但与对照组相比，整个孕期均显著较低。MPXI和LI之间没有显著关联。可以推测，妊娠中期MPXI的下降是由于中性粒细胞脱颗粒，而妊娠末期的升高可能是雌激素影响下MPO活性增强的结果。低LI表明妊娠期间产生了未成熟的中性粒细胞。
