间变性淋巴瘤激酶（AlK）基因的小鼠同源基因在小鼠第17号染色体上的定位。

Localization of the murine homolog of the anaplastic lymphoma kinase (AlK) gene on mouse chromosome 17.

作者信息

Mathew P, Morris S W, Kane J R, Shurtleff S A, Pasquini M, Jenkins N A, Gilbert D J, Copeland N G

机构信息

Department of Experimental Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101-0318, USA.

出版信息

Cytogenet Cell Genet. 1995;70(1-2):143-4. doi: 10.1159/000134080.

DOI:10.1159/000134080

PMID:7736780

Abstract

The murine homolog of the human anaplastic lymphoma kinase gene, which encodes a membrane-spanning receptor tyrosine kinase in the insulin receptor kinase subfamily, was assigned to mouse Chromosome 17 by interspecific backcross analysis. This assignment further confirms the homology between a portion of the distal Chromosome 17 and the short arm of human chromosome 2 and extends this region in the mouse by an additional 3 cM.

摘要

人类间变性淋巴瘤激酶基因的小鼠同源基因，在胰岛素受体激酶亚家族中编码一种跨膜受体酪氨酸激酶，通过种间回交分析被定位到小鼠第17号染色体上。这一定位进一步证实了小鼠第17号染色体远端的一部分与人2号染色体短臂之间的同源性，并将小鼠中的这一区域又扩展了3厘摩。