Haase J, Ozaki Y, Di Mario C, Escaned J, de Feyter P J, Roelandt J R, Serruys P W
Thoraxcenter, Erasmus University Rotterdam, The Netherlands.
Eur Heart J. 1995 Jan;16(1):112-9. doi: 10.1093/eurheartj/16.1.112.
In 62 patients with angina pectoris Canadian Class III and IV, the luminal dimensions of 25 pre-PTCA and 56 post-PTCA lesions without occlusion were examined with a 4.3 F 30 MHz mechanical ultrasound imaging catheter, and analysed off-line using ultrasound cross-sectional area (U-CSA) measurements from s-VHS video images (n = 81). In addition, 42 angiographically normal coronary segments were examined. At the site of the examination, the U-CSA was integrated centrally to the leading edge echo of the inner contour of the vessel wall and the corresponding angiographic cinefilm images were analysed by edge detection using the Cardiovascular Angiography Analysis System. The obstruction diameter (at the lesion) and the mean vessel diameter (at normal sites) were used to calculate the angiographic cross-sectional area (A-CSA) assuming a circular model. U-CSA values were compared with the corresponding A-CSA values using t-test and linear regression analysis. The study showed that larger CSA are measured with ultrasound than with angiography. (P < 0.0001). An acceptable correlation was found between U-CSA and A-CSA values in normal coronary segments (correlation coefficient: r = 0.73, mean diff. = 1.44 +/- 1.22 mm2). However, the correlation was poor at the site of pre-PTCA lesions (r = 0.62, mean diff. = 1.81 +/- 1.14 mm2) and deteriorated following PTCA (r = 0.47, mean diff. = 1.28 +/- 2.20 mm2). No correlation was found between the degree of lumen eccentricity measured with intracoronary ultrasound (ICUS) and the individual differences between U-CSA and A-CSA values.(ABSTRACT TRUNCATED AT 250 WORDS)
在62例加拿大心血管学会（CCS）分级为III级和IV级的心绞痛患者中，使用4.3F 30MHz机械超声成像导管检查了25处PTCA术前和56处PTCA术后无闭塞病变的管腔尺寸，并使用来自s-VHS视频图像的超声横截面积（U-CSA）测量值进行离线分析（n = 81）。此外，还检查了42个血管造影正常的冠状动脉节段。在检查部位，U-CSA集中于血管壁内轮廓前缘回声的中心进行整合，并使用心血管造影分析系统通过边缘检测对相应的血管造影电影图像进行分析。假设血管为圆形模型，使用阻塞直径（病变处）和平均血管直径（正常部位）计算血管造影横截面积（A-CSA）。使用t检验和线性回归分析将U-CSA值与相应的A-CSA值进行比较。研究表明，超声测量的横截面积大于血管造影测量值（P < 0.0001）。在正常冠状动脉节段中，U-CSA和A-CSA值之间存在可接受的相关性（相关系数：r = 0.73，平均差值 = 1.44±1.22mm²）。然而，在PTCA术前病变部位相关性较差（r = 0.62，平均差值 = 1.81±1.14mm²），PTCA术后相关性进一步恶化（r = 0.47，平均差值 = 1.28±2.20mm²）。冠状动脉内超声（ICUS）测量的管腔偏心程度与U-CSA和A-CSA值之间的个体差异无相关性。（摘要截短于250字）
